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The challenges faced by the nanomaterials in the process of clinical translation are highly complex due to the fate of nanomaterials in vivo, specifically stability issues as it is exposed to various biological systems, safety/toxicity issues due to bio-accumulation of non-degradable materials, and so on
Establishing comprehensive profiles of biodistribution, biodegradation, clearance, and long-term immunological consequences is the prerequisite for solving this problem
