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One study found out that treating infertile men with varicocele with a host of oxidants including B12 for a period of 3 months has found out that on an average, it was found that patients have 31.3% lesser degraded sperm cells and a decrease of 22.1% in sperm DNA fragmentation after this treatment

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While biotin deficiency is relatively uncommon, individuals with certain metabolic conditions, those taking long-term medications such as anticonvulsants, or patients with poor nutritional absorption may benefit from intramuscular administration

[36] Vitamin B 12 deficiency is most commonly caused by malabsorption, but can also result from low intake, immune gastritis, low presence of binding proteins, or use of certain medications