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From Steatosis to Inflammation and Fibrosis: A Convergent Model The pathological progression from simple steatosis to steatohepatitis and fibrosis is a multifactorial process governed by complex molecular mechanisms that are largely shared between MASLD and alcoholic liver disease (ALD) [77]

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For instance, a recent study showed that implantation of the electrospun nanofiber scaffolds promotes polarization of macrophages toward a pro-regenerative (M2) phenotype and a consequent decrease in the M1/M2 ratio and scarring/fibrosis at the nerve injury site, and concomitantly, a higher number of regenerated axons [69]

Tiffin N, Adi S, Stokoe D, Wu NY, Rosenthal SM (2004) Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation