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Such HIF-dependent expression is also known as selective mitophagy (Mazure and Pouyssegur, 2010)

The NRF2 Signaling Pathway Activation of NRF2 signaling can be initiated via a variety of mechanisms, ranging from oxidative stress to autophagic dysfunction to mutations in NFE2L2 /NRF2 or its negative regulators that result in its constitutive activation