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Spinal surgery to remove the degenerated disc and fuse the adjacent spinal segments may cause degeneration and instability of the neighboring discs (Karppinen et al., 2011)

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

Biological Targets for Weight-Loss Drug Development Figure 2: Simplified schematic overview of biological pathways targeted by weight-management drugs 3

Managing stress supports healthy levels