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RARalpha/RXR synergism potentiates retinoid responsiveness in cutaneous T-cell lymphoma cell lines

The key regulatory axes in glutamine metabolism reprogramming include the MYC-driven transcriptional activation of glutamine catabolic enzymes, mTORC1-mediated potentiation of anabolic pathways, and suppression of -KG dehydrogenase by hypoxia-inducible factor (HIF)-1, which collectively diverts glutamine carbon toward nucleotide synthesis (purine/pyrimidine), FA production (via reductive carboxylation), and TCA cycle anaplerosis (66)

224,225,226 Additionally, Klotho enhances insulin sensitivity in peripheral tissues, including muscle and adipose tissue, and has neuroprotective functions through the modulation of neuronal signaling pathways