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Superseded by Fanidi, 2019

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Alcohol can impair hepatic gluconeogenesis and may mask the symptoms of hypoglycemia, making detection and treatment more challenging

This absence of hyperglycemic effects makes the peptide safer for individuals concerned about glucose metabolism, and the lack of IGF-1 elevation reduces theoretical concerns about cell proliferation