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As could be expected, the activity of core astrocyte-specific enzymes depend upon the formation of astrocytes, although some enzymes that later become astrocyte-specific are neuronal during early development

The possible involvement of sensory neurons in the salutary effects of NaBPC157 (10 g/kg, 10 ng/kg i.p.) was studied with capsaicin which has quite distinct effects on sensory neurons: high dose administration to adult animals (125 mg/kg s.c., (subcutaneously) three months of age) or administration (50 mg/kg s.c.) to neonatal animals (seven days of age) destroys sensory fibers, whereas a low dose (500 g/kg i.p.) activates a neurotransmitter release and protective effects on the mucosa

Rebouche, FASEB J

Designing nanozymes for in vivo applications