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In states of insulin resistance, hepatic steatosis, and renal impairment, mitochondrial electron transport chain dysfunction drives the excessive production of ROS, which results in redox imbalance and metabolic stress (96, 97)

indica showed higher POD and CAT activities under NW conditions, suggesting that WS had an inhibitory effect on POD and CAT activities of white clover, which are the main enzymes for H 2 O 2 scavenging (Du et al., 2001)

Furthermore, a genotype study also reported that homozygous TT genotype of MTHFR was also associated with risk of schizophrenic patients accompanying with bipolar disorder 46