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It is for researchers and study-readers orienting themselves in this literature

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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

While these advances mark significant progress, several challenges persist, including resistance, high relapse rates, and limited diagnostic resources