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Chewing tobacco can be in the form of leaf tobacco (which is packaged in pouches), or plug tobacco (which are packaged in "brick" form)

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Methods/design Study design This clinical trial will use a double-blind, placebo-controlled, dose escalation design, with random assignment of participants to an experimental (group A) and a control condition (group B) for 10 weeks after failure to achieve abstinence during an open-label run-in period of approximately 2 weeks using a 21-mg nicotine patch daily

The cigarette box can be wrapped individually or collectively(use 10 packs model)