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In particular, levels of L-arginine, L-proline, and L-glutamic acid were elevated, whereas glutathione, L-tyrosine, and L-phenylalanyl-L-proline levels were reduced

27 A few botanical therapies are: Systane (Alcon)

10.1038/s41423-022-00905-x 203 WeissT.WellerM.RothP

These findings seem to parallel the inhibitory effects of bilirubin on superoxide production32 and on overall mitochondrial metabolism.33 In fact, pyrrole groups of bilirubin, present also in our compounds, have been suggested to compete with NADH on the active sites of mitochondrial dehydrogenases indicating possible mechanisms of these effects.33 This conclusion is also in accord with a report by Boloor, et al., who described marked protective effects of chlorophyllin on mitochondria-induced lipid peroxidation.34 It seems that observed anti-carcinogenic effects are mediated, at least partially, by direct inhibition of mitochondrial ROS generation