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The use of this kind of control sample allows for the establishment of reference ranges for each compound and therefore facilitates the identification of any compounds or pathways outside the reference range in a single patient

At lower concentrations of APE (62.5 and 125 g/mL), a modest decline in NO levels was observed, while higher concentrations (250, 500, 1000, and 2000 g/mL) exhibited progressively stronger suppression of NO production, greater than 50%

Secondly, the identification of specific molecular targets and pathways through which AS-IV exerts its effects could facilitate the design of targeted clinical trials, allowing for a more precise understanding of its mechanisms of action

Hiraga T, Hata T, Soya S, Shimoda R, Takahashi K, Soya M, et al