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In AML, alterations in histone methylation can impact the expression of critical tumor suppressor genes and contribute to drug resistance ( A histone methyltransferase, EZH2, catalyzes the trimethylation of H3K27, leading to changes in gene expression

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PPP becomes the major metabolic route during oxidative burst Interdependence between the activation of oxidative burst and rewiring of PPP suggests that neutrophils probably redirect glucose into oxPPP to increase NADPH supply