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In addition, real-world scenarios involve exposure to multiple toxins simultaneously, and understanding the combined or synergistic effects of such mixtures remains a complex and underexplored area [395]

Responsible breeders prioritise balanced nutrition in their puppies' diets, often ensuring proper nutrient intake including L-Carnitine

Elevated ROS levels associated with inflammation, carcinogenesis, aging, and photobiological effects, can disrupt redox homeostasis and impede wound healing [35, 37, 38]

Nonetheless, the study identified a clear trend of more prevalent metabolic vitamin B 12 deficiency (measured as cB 12 ) with increasing age (Risch et al., 2015)