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NAD injections are sometimes offered as a lower-cost alternative to IV therapy

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At low doses of APAP there is little effect while the hepatotoxicity increases rapidly at high doses

This review synthesises current knowledge on (i) nasal anatomy and physiological determinants of absorption and deposition, (ii) the formulation approaches for intranasal drug delivery systems, and (iii) device technologies designed to improve targeting, particularly toward the olfactory region for potential nose-to-brain delivery