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As both play very important roles in the immune response, and the status or availability of one has been shown to directly affect the other, it is likely that deficiency of either can have a direct effect on the severity of COVID-19 as well as many other diseases therefore, taking steps to ensure adequate levels of both is essential to better health

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In Tregs, dexamethasone enhanced immunosuppressive activity by reducing glycolysis and increasing oxidative phosphorylation through miR-342-dependent inhibition of rapamycin-insensitive companion of mTOR (RICTOR) (186)