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As a result, recent efforts have focused on the outcomes of TDP-43 mislocalization as early markers of dysfunction and/or mechanisms driving disease

Key challenges in oral delivery of cyclic peptides The poor oral bioavailability of cyclic peptides stems from numerous interdependent factors, including physicochemical constraints, gastrointestinal (GI) tract biology, enzymatic degradation, active efflux, and first-pass metabolism, which result in low and variable oral absorption: 1

245,251,252,253,254 In addition, astrocytes can be infected and can serve as a viral reservoir