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Although not essential for enzymatic conversion of peroxide to oxygen, the NADPH appears to protect catalase from inactivation by peroxide

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J Clin Invest 1967;46(12): 19861998

This antitumor effect was associated with a shift toward an immunostimulatory tumor-associated macrophage (TAM) phenotype and an enhanced effector T cell response within the tumor microenvironment, mediated by activation of the type I Interferon pathway (238)