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Yakar, S

Friedman does not recommend GLP-1s in patients with low muscle mass to begin with

Loose skin has lost the strength and support of the collagen network that exists at the deepest layers of the skin

Insulin resistance, hyperinsulinemia, dyslipidaemia, and obesity precede the progression to T2D in 7585 % of patients [65], and the presence of MetS increases up to fivefold the risk for T2D compared to individuals without MetS [66, 67]