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Objective: There are major challenges that worsen the outcome of hyperammonemic individuals in the Middle East

Thus, regulating MUFA levels, especially oleic acid content, is highly important to ameliorate the malignant progression of CCA

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Notably, the oxidative stress compromises tubular cell and parenchymal integrity and deteriorates renal function by downregulating SIRT1/PGC-1-Mfn2 signaling