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Unlike iron - which can induce non-specific oxidative damage through Fenton reactions - or zinc, which contributes to structural and catalytic stability without participating in redox cycling, copper supports tightly regulated electron transfer and dynamic, chaperone-mediated signaling processes via proteins such as Atox1

Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways

The 1mg arm was a fixed low-dose cohort with no escalation