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Description

ALS patients with SOD1 mutations of conserved residues were found to have shorter life span as well as shorter time between the disease onset and respiratory failure

FACS confirmed that the results are consistent with the observation (Figure 3C)

Chen D, Chan R, Waxman S, Jing Y: Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH 2 -terminal kinase and up-regulation of death receptors