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Lastly, previous work by us and others showed that Fun30 and SMARCAD1 are targets of post-translational modification, particularly CDK phosphorylation (Chen et al, 2016

TABLE 1 Key health-related toxicity endpoint information

Su et al., 2023)

Effect of biased agonism on OR desensitization The first reports describing a differential desensitization of MOR, DOR, and KOR by various agonists came from Reisine's group (Blake et al., Biased agonism at MOR and desensitization Functional studies revealed that [D-Ala 2 -MePhe 4 -Gly 5 -ol]enkephalin (DAMGO) induced a stronger desensitization of MOR than morphine in different experimental models and signaling pathways (Yu et al., 1997