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doi: 10.1016/j.bpj.2022.06.021 8 SunFSchroerCFEPalaciosCRXuLLuoSZMarrinkSJ

43), which leverages a pH- and NIR laser-dual-responsive nano-PROTAC platform [130]

The diabetic environment often results in impaired wound healing processes for DFU, mainly attributed to excess oxidative stimulation, prolonged inflammation, dysfunction of immune cells, delayed reinnervation, and reduced angiogenesis at the wound site [113, 114]