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doi: 10.2337/dbi18-0057 316 ThomasECHookSCGrayAChadtACarlingDAl-HasaniHet al

TNF-, a proinflammatory cytokine, promotes immune cell recruitment and cell death by inducing the expression of cytokines, chemokines, adhesion molecules, cyclooxygenase-2, and inducible nitric oxide synthase or by activating signaling pathways such as the NF-B, STAT, and PPARs pathways