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Gene expression analysis using the Broad Institute Connectivity Map The authors analysed how GHK-Cu affects human gene expression using the Connectivity Map (CMap) a massive database developed at MIT and Harvard that maps how compounds alter gene activity

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Larger trials would provide more precise effect estimates and detect smaller differences between groups

To allow epithelial renewal and ISCs turnover, MCs, as well as epithelial cells, produce Wnt, Notch and Hedgehog ligands, epidermal growth factor (EGF), inhibitors of the bone morphogenic pathways (BMP) and prostaglandin E2 (PGE2) [36, 37]