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Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use GLP-1 receptor agonists due to thyroid C-cell tumor risk observed in animal studies

Study design The Phase 2 trial was a randomized, double-blind, placebo-controlled study that enrolled 338 adults with obesity (BMI 30 or higher) or overweight (BMI 27 or higher) with at least one weight-related condition

These cells remain metabolically active, adopt a distinct phenotype (including chromatin changes), and critically secrete a variety of pro-inflammatory cytokines, proteases, growth-factors and extracellular-matrix modifying signals

34 = 11,3 5 Amino 1MQ, ,