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She has developed and clinically evaluated strategies that render T cells resistant to inhibition by the tumor microenvironment, such as a dominant-negative TGFb receptor, a single chain interleukin (IL)-12 and a constitutively active IL-7 receptor (C7R), as well as an inducible caspase 9 suicide safety switch for gene-modified T-cells, all of which subsequently have proved successful in clinical trials