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For each animal 3 10 6 HT-29 cells were mixed 1:1 v/v with LDEV-free extracellular matrix protein Geltrex (Gibco, # A1413201) and inoculated by subcutaneous injection in the right flank

STZ-treated TRPC1/4/5/6 / mice presented decreased endothelial and pericyte cell death that led to retinal thickness preservation, as well as lower concentrations of MG in plasma and red blood cells, and enhanced expression and activity of glyoxalase 1 (GLO1), the major MG detoxification enzyme, compared to control (Sachdeva et al., 2018)