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eLife 12 , RP91861 (2023)

Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2, TLR4, TNF- IL-1, and NFB expression levels

By inhibiting drug efflux pumps, suppressing pro-survival pathways (e.g., NF-B, PI3K/Akt/mTOR), and augmenting apoptotic signaling, curcumin can lower the effective dose of chemotherapy required to achieve a desired cytotoxic effect, potentially reducing dose-limiting toxicities