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The mitochondria-specific autophagy process, also known as mitophagy, ultimately results in mitochondria engulfment and degradation [10, 11] which has been demonstrated experimentally where the systemic knockout of Parkin in mice resulted in elevated intracellular ROS levels in the VTA and a reduction in proteins involved in ETC and oxidative stress regulation [37]

Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation: an open-label pilot study

doi: 10.17179/excli2019-1447

Indoxyl sulfate activates NLRP3 inflammasome to induce cardiac contractile dysfunction accompanied by myocardial fibrosis and hypertrophy