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BmK AGAP, a potential candidate molecule, has demonstrated heterologous expression and maintained its pharmacological effects while increasing its yield

In general, the amino heterocycle strongly contributes to binding, in fact, the positively charged amino group forms a salt bridge with Glu467 (N-O distance: 2.7 for piperazine, 3.6 for piperidine), while the other main interactions are hydrophobic and involve Ile339, Phe396, Leu399 (Figure 4B)

Some CBS variants cause the enzyme to work too quickly, rapidly depleting homocysteine by shunting it down the transsulfuration pathway

Wang Liao is the recipient of the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001) and the Zhishan Young Scholar Award at the Southeast University