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Iron metabolism, in turn, affects immune homeostasis through a variety of complex mechanisms, including promoting toxic stress, inducing inflammatory responses, and damaging immune cells, leading to the development of RA

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85 This is of particular importance because some xenobiotics might impact the GI microbiota physiology without inducing dysbiosis: indeed, when fresh human faecal samples were incubated with antibiotics or with host-targeted drugs, all host-targeted drugs resulted in significant alterations of microbial gene expression, including genes involved in xenobiotic metabolism, despite minimal short-term effects on microbial community structure

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