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The 3-fold increased risk of ESKD in African Americans compared to European Americans is currently mainly attributed to variants in the APOL1 gene in the chromosome 22q12 locus

Hcy is implicated in cardiovascular disease through diverse mechanisms, including the heightened proliferation of muscle cells leading to vessel constriction, modification of blood coagulation properties, oxidative damage to the vascular endothelium, and harm to arterial walls [49]

The limited success of iron chelators used in neurological disorders has led to the exploration of optimized drug delivery systems that can overcome these barriers (Cecchelli et al., 2007)

Hall MG, Alhassoon OM, Stern MJ, Wollman SC, Kimmel CL, Perez-Figueroa A, et al