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OCR was significantly blocked, and ATP production, basal respiration, and maximal respiration were significantly decreased after COM treatment compared to that in the control group

doi:10.1016/j.fct.2013.03.024

(555) Garcia-Monco, J

This is corroborated by another study where biogenic spherical SeNPs, synthesized using Asteriscus graveolens leaf extract, induce ROS overproduction and mitochondrial membrane potential (MMP) disruption, thus evidencing their high antitumor activity against HepG2 cells through the activation of apoptosis pathways (Figure 11) [285]