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352 A bisubstrate inhibitor comprises two covalently linked fragments, each binding to a substrate or cofactor element, potentially mimicking the ternary transition state of a bireactant-catalyzed reaction

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Conclusion: These studies reveal that deletion of the BA etiologic gene Pkd1l1 leads to increased expression of pro-inflammatory mediators in mouse cholangiocytes, both basally and in response to LPS