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Horikawa N, Abiko K, Matsumura N, Hamanishi J, Baba T, Yamaguchi K, et al

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Commonly used measures (e.g., nerve conduction velocity, IENFD, and circulating inflammatory markers) each carry known variability and interpretive constraints, and emerging tools such as quantitative MR neuroimaging or minimally invasive sampling techniques have not yet been consistently integrated with pharmacokinetics, target engagement, and functional outcomes into a unified evidentiary chain (Winter et al., 2002