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Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria

Immunology Letters

In keeping with this hypothesis, 1,2,3- 13 C 3 -glucose tracing highlights significant decreases in 13 C 3 -pyruvate labeling and the ratio of 13 C 3 -pyruvate/ 13 C 3 -lactate, while flux through glycolysis versus the pentose phosphate pathway is unaltered as gleaned by the ratios of isotopologues M+2/M+3 of lactate ( Figure 3B )