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Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity

In addition, the G6PD A variants have a second mutation, and in the majority of cases it is at nucleotide 202 (GA)

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To this end, we employed a swine model with DM and CKD, and in a comprehensive approach, combined unbiased proteomic assessment of changes in myocardial signaling pathways with direct measurements of cardiac and coronary microvascular function in vivo, mitochondrial function ex vivo, and detailed histological and molecular assessment of myocardial fibrosis and oxidative stress