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These effects were contributed to benfotiamine's action on transcription factors NF-B and Egr-1, arachidonic acid pathway, protein kinase C and members of MAPK signaling cascade p38, ERK1/2, SAPK/JNK [14,15]

Standard corneal transplantation with mechanically tough human donor tissue often results in scar tissue formation at host-to-implant interfaces 50,60 , a phenomenon we did not observe with the mechanically softer BPCDX