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However, each metabolic intermediate in the DNL pathway (i.e., citrate, acetyl-CoA, malonyl-CoA, and palmitate) also has second messenger functions

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These may include: A persistent or intermittent metallic, bitter or chemical taste Reduced ability to detect sweet, salty or sour flavours Dry mouth or thick saliva Burning or irritation on the tongue Bad breath or unusual mouth odour Sensitivity to hot or spicy foods Changes in appetite or food enjoyment Bleeding gums, swelling or tenderness Sinus congestion, sore throat or post nasal drip Signs of reflux, such as heartburn or coughing at night The metallic taste may be present even without eating or drinking and may be worse in the morning or after meals