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Once riboflavin enters the cell, RFK catalyzes the rate-limiting phosphorylation of vitamin B2 to flavin mononucleotide (FMN), which is subsequently adenylated by FLAD1 to form FAD (Fig

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Devall M, Soanes DM, Smith AR, Dempster EL, Smith RG, Burrage J, Iatrou A, Hannon E, Troakes C, Moore K, ONeill P, Al-Sarraj S, Schalkwyk L, Mill J, Weedon M, Lunnon K (2022) Genome-wide characterization of mitochondrial DNA methylation in human brain

2) Cell type- and subtype-specific regulatory blank spots: Most studies have centered on podocytes and TECs, but the role of renal non-parenchymal cells (e.g., mesangial cells, renal endothelial cells, and inflammatory cells) in ferroptosis-driven DN is understudied