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The majority of nicotine in humans is metabolized to cotinine, and cotinine is further metabolized to trans-3'-hydroxycotinine (3HC) [21]

The researchers, led by Nicola Lindson-Hawley from the UK Centre for Tobacco and Alcohol Studies at the University of Nottingham, looked at the quit rates of both groups at four weeks and at six months and found that smokers in the abrupt group were 25% more likely to stop smoking overall, regardless of whether they originally expressed a preference for quitting abruptly or gradually