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[DOI] [PMC free article] [PubMed] [Google Scholar] Eberle D., Clarke R., Kaplowitz N

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

It is known that symptoms of schizophrenia are well characterized, but the mechanism underlying the pathogenesis of this disease still remains unknown