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This oxidative interference leads to depletion of phosphatidylinositol 3-phosphate (PI(3)P), a hallmark lipid of early endosomes, causing endosomal dysfunction in prostate cancer cells

Embodiment 170 The method of embodiment 169, wherein the contacting is performed in vivo

However, oxaliplatin-induced peripheral neurotoxicity (OIPN) is a severe dose-limiting clinical problem that might lead to treatment interruption (Daz-Rubio et al., 1998