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"1938 election results" (PDF)

doi:10.1136/tc.2011.043448

Similar to the effects seen by overexpression of MnSOD in the mitochondria, mtDNA induced lung inflammation was enhanced in mice with a deleted aconitase-2 (ACO-2) gene ( 2 by the mitochondria, leading to oxidation and inactivation of the ACO-2 substrate, and hence further accumulation of citrate to promote increased mtDNA synthesis