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Glucose-6-phosphate will metabolically trifurcate into the following pathways: (i) conversion to fructose-6-phosphate by the enzyme phosphoglucose isomerase, entering the glycolytic pathway, or (ii) oxidation by glucose-6-phosphate dehydrogenase to 6-phosphogluconolactone, thereby initiating the oxidative phase of the pentose phosphate pathway

LLPS occurs in glial cell types, including astrocytes, microglia, and oligodendrocytes, where its dysregulation is implicated in neuroinflammation, demyelination, and the pathogenesis of neurodegenerative diseases

However, experimental evidence suggests that they include increased concentration of the drugs in the hepatobiliary compartment, formation of reactive metabolites that covalently modify proteins and produce oxidative stress, and mitochondrial injury