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Masterjohn: The Sigma-1 receptor is still poorly understood in terms of its overall function, but we at least know that it appears to be involved in the stress response because it is necessary for the response to cortisol

Therefore, it is particularly urgent to explore the role of FOXO4-DRI in vascular aging research

Additionally, they enhance skin-resident Treg function through glucocorticoid receptor-dependent signaling and support hair follicle stem cell activation [110]