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In addition, impaired glymphatic or paravascular clearance in AD may alter the elimination of brain-delivered nanoparticles, potentially affecting retention, regional distribution, and long-term safety during repeated dosing ( 6 Opportunities, challenges, and future directions In recent years, nanoparticles have emerged as a promising strategy in AD therapy, offering considerable potential for precise drug delivery while presenting challenges that must be carefully addressed by researchers

5 These unusual properties make it an intriguing candidate as a therapeutic agent

Evidence of signalling pathways regulating tumour cell invasion may be found within the tumour itself through detailed IHC analysis

Oral formulations may require longer durations given the bioavailability uncertainty